腺苷脱氨酶/ADA/Adenosine Deaminase

 Description
Analysis Note Protein determined by biuret.
Biochem/physiol Actions Adenosine deaminase is a purine catabolic enzyme which catalyzes the deamination of adenosine and 2′-deoxyadenosine with approximay equal specificity. It is ubiquitous in mammalian tissue, and deficiency in adenosine deaminase has been associated with severe combined immunodeficiency disease. The enzyme has been tested as a target for gene therapy treatments of this disease.
General description Molecular weight: 32.5-33 kDa
pI: 4.85
Unit Definition One unit will deaminate 1.0 μmole of adenosine to inosine per min at pH 7.5 at 25 °C.
Physical form Suspension in 3.2 M （NH4）2SO4, 0.01 M potassium phosphate, pH 6.0

Properties
type Type IX
form ammonium sulfate suspension
foreign activity 5′-AMP deaminase ≤0.01%
  alkaline phosphatase ≤0.01%
  guanase ≤0.01%
  nucleoside phosphorylase ≤0.1%
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator （EU）, half-mask respirator （US）, multi-purpose combination respirator cartridge （US）
Safety Statements 23-24/25
WGK Germany 3
 

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