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产品名称：
L-甲状腺素/O-（4-羟基-3,5-二碘苯基）-3,5-二碘-L-酪氨酸/L-Thyroxine
产品型号： A0170更新时间： 2017-08-02描述：Synonym: 3,3′,5,5″-Tetraiodo-L-thyronine, T4, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine CAS Number: 51-48-9 Linear Formula: HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H Molecular Weight: 776.87 Beilstein Registry Number: 2228515
产品介绍
Description
Biochem/physiol Actions L-Thyroxine （T4） and triiodo-L-thyronine （T3） are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.
Properties
assay ≥98% （HPLC）
mp 223 °C （dec.）（lit.）
Gene Information human ... TTR（7276）
rat ... Cnr1（25248）
mouse ... Cnr2（12802）
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements 22-24/25
WGK Germany 3
RTECS YP2833500
References
reference Oppenheimer, J.H., et al., Advances in our understanding of thyroid hormone action at the cellular level. Endocr. Rev. 8, 288-308, （1987）
DeGroot, L.J., and Niepomniszcze, H., Biosynthesis of thyroid hormone: basic and clinical aspects. Metabolism 26, 665-718, （1977）
Dussault, J.H., and Ruel, J., Thyroid hormones and brain development. Annu. Rev. Pharmacol. Toxicol. 49, 321-334, （1987）
Evans, R.M., The steroid and thyroid hormone receptor superfamily. Science 240, 889-895, （1988）
Merck Merck 13,9491
Beilstein Beil. 14,IV,2373
Aldrich MSDS 1, 1709:B / Corp MSDS 1 （2）, 3349:B / FT-IR 1 （2）, 254:B / FT-IR 2 （2）, 2749:A / RegBook 1 （2）, 1845:F / Sigma FT-IR 1 （1）, 724:B / Structure Index 1, 296:B:1
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