磺胺嘧啶/磺胺嘧啶钠/2-对氨基苯磺酰胺嘧啶/磺胺哒嗪/地亚净/Sulfadiazine

Description
Biochem/physiol Actions Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Properties
assay ≥99.0%
mp 253 °C （dec.）（lit.）
suitability suitable for 1694 per US EPA

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements 22-36/37/38-42/43
Safety Statements 26-36
WGK Germany 3
RTECS WP1925000

References
reference Then, R.L., Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole. Rev. Infect. Dis. 4, 261-269, （1982） Abstract
  Skold, O., Sulfonamide resistance: mechanisms and trends. Drug Resist. Updat. 3, 155-160, （2000） Abstract
Merck Merck 13,8988
Beilstein Beil. 25,IV,2097
  Corp MSDS 1 （2）, 3195:A / FT-IR 2 （3）, 3872:A / FT-NMR 1 （3）, 392:A / RegBook 1 （2）, 2587:C / Sax 6, 2338 / Sigma FT-IR 1 （1）, 713:D / Structure Index 1, 409:C:4

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