盐酸阿霉素/盐酸多柔比星/盐酸柔红霉素/阿得里亚霉素/14-羟正定霉素/阿霉素/DOX

Description
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Biochem/physiol Actions Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles （Golgi and lysosome） in the sequestration of drugs and its implication in drug resistant phenotypes.
  Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA;1 Properties.2,3
  Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Legal Information Adriamycin is a registered trademark of Farmitalia Carlo Erba S.R.L.

Properties
assay ≥98% （TLC）
mp 216 °C （dec.）（lit.）
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 45-22
Safety Statements 53-45
WGK Germany 3
RTECS QI9295900

References
Cited Reference 1. C.N. Ellis et al. Biochem. J. 245, 309, （1987）
  2. R.J. White et al. Drugs Pharm. Sci. 22, 569, （1984）
  3. A. Vigevani, M.J. Williamson Anal. Profiles Drug Subst. 9, 245, （1980）
reference Gong, Y., et al. J. Biol. Chem. 278, 50234-50239, （2003） Abstract
  Rajagopal, A., and Simon, S.M. Mol. Biol. Cell 14, 3389-3399, （2003） Abstract
  Friesen, C., et al., Cytotoxic drugs and the CD95 pathway. Leukemia 13, 1854, （1999）
  Kraus-Berthier, L, et al., Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clin. Cancer Res. 6, 297-304, （2000）
  Sparano, J.A., Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Semin. Oncol. 26, 14-19, （1999）
Merck Merck 13,3473
  Aldrich MSDS 1, 849:A / Corp MSDS 1 （1）, 1499:A / RegBook 1 （2）, 1691:D / Sax 6, 144 / Structure Index 1, 268:B:6

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