秋水仙胺/脱碳秋水仙碱/Demecolcine

 Description
Biochem/physiol Actions Depolymerizes microtubules; blocks mitosis at metaphase.
Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
Legal Information Colcemid is a trademark of Ciba-Geigy AG

Properties
assay ≥98% （HPLC）
solubility DMSO: 10 mg/mL
  ethanol: soluble
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 25
Safety Statements 22-24/25-45
RIDADR UN2811 6.1/PG 2
WGK Germany 3
RTECS GH0800000

References
reference Nishiyama, I., and Fujii, T., Laminin-induced process outgrowth from isolated fetal rat C-cells. Exp. Cell Res. 198, 214-220, （1992） Abstract
Merck Merck 13,2906
Beilstein Beil. 14,IV,940

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