腺苷/腺嘌呤核苷/9-β-D-呋喃核糖基腺嘌呤/腺素苷/胰苷/腺呤配糖/腺尿环核苷/Adenosin

 Description
Biochem/physiol Actions Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplaet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease （COPD）.

Properties
assay ≥99%
mp 234-236 °C（lit.）
Gene Information human ... ADA（100）, ADORA1（134）, ADORA2A（135）, ADORA2B（136）, ADORA3（140）, ERBB2（2064）, ERBB4（2066）
  rat ... Adcy2（81636）, Adora1（29290）, Adora2a（25369）, Adora3（25370）
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
WGK Germany 2
RTECS AU7175000

References
reference Hutchinson, S.A., and Scammells, P.J., A1 adenosine receptor agonists: medicinal chemistry and therapeutic potential. Curr. Pharm. Des. 10, 2021-2039, （2004）
  Fredholm, B.B., et al., Actions of Adenosine at Its Receptors in the CNS: Insights from Knockouts and Drugs. Annu. Rev. Pharmacol. 27, （2004）
  Livingston, M., et al., Adenosine, inflammation and asthma--a review. Inflamm. Res. 53, 171-178, （2004）
  Sullivan, G.W., Adenosine A2A receptor agonists as anti-inflammatory agents. Curr. Opin. Investig. Drugs 4, 1313-1319, （2003）
  Rorke, S., and Holgate, S.T., Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Med. 1, 99-105, （2002）
Merck Merck 13,154
Beilstein Beil. 26,IV,3598
  FT-IR 1 （2）, 720:A / FT-IR 2 （3）, 3684:C / FT-NMR 1 （3）, 222:A / IR-Spectra （3）, 1296:E / IR-Spectra （2）, 1128:F / NMR-Reference 2 （2）, 597:C / RegBook 1 （2）, 2475:K / Sax 6, 138 / Sigma FT-IR 1 （1）, 752:C / Structure Index 1, 391:A:6

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