环磷酸腺苷/环腺苷酸/腺苷-3′5′-环磷酸/Cyclphosphate/CAMP

 Description
Biochem/physiol Actions Naturally-occurring activator of cyclic-AMP-dependent protein kinase （PKA）. cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Properties
assay ≥99% （HPLC）
form powder
color white
mp 260 °C （dec.）（lit.）
solubility H2O: 10 mg/mL, clear, colorless （pH of aqueous solution is approx. 3.0. The sodium salt （A6885） is about 20× more soluble.）
Gene Information human ... OPRK1（4986）
storage temp. −20°C

Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements 22-24/25
WGK Germany 3
RTECS AU7357600

References
reference Daniel, P.B., et al., Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18, 353-383, （1998）
  Spada, A., et al., Cyclic AMP and calcium in the transduction of hypothalamic neurohormone action in human pituitary tumors. Horm. Res. 47, 235-239, （1997）
  Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78, 165-174, （1998）
Merck Merck 13,2737
Beilstein Beil. 26,IV,3618
  FT-IR 1 （2）, 725:A / FT-IR 2 （3）, 3691:C / FT-NMR 1 （3）, 229:A / IR-Spectra （2）, 1133:G / IR-Spectra （3）, 1301:F / NMR-Reference 2 （2）, 605:D / RegBook 1 （2）, 2481:D / Sigma FT-IR 1 （1）, 805:C / Structure Index 1, 392:D:3

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