毛地黄皂苷/洋地黄皂苷/毛地黄皂甙/毛地黄叶苷/地芰脱皂苷/Digitonin/Digitin

 Description
Frequently Asked Questions Live Chat and Frequently Asked Questions are available for this Product.
Application Mild nonionic detergent used to solubilize receptors and permeabilize cellular and nuclear membranes.
Quality Preparation is free of water-insoluble constituents.

Properties
optical activity [α]20/D −54°, c = 2.8 in methanol（lit.）
mol wt micellar avg mol wt 70,000
aggregation number 60
color white
CMC <0.5 mM（20-25°C）
mp 230-240 °C （dec.）（lit.）
solubility H2O: 5 % （w/v） （solubilized by heating to 95 °C - 98 °C and then cooling to room temp.）

Safety
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 22-28-36/37-45
RIDADR UN3462 6.1/PG 3
WGK Germany 3
RTECS IH2050050

References
reference Karl, J., et al., GFAP phosphorylation studied in digitonin-permeabilized astrocytes: standardization of conditions. Brain Res. 853, 32-40, （2000） Abstract
  Liu, J., et al., Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking. Methods 19, 403, （1999） Abstract
  Prehm, S., et al., A mild purification method for polysaccharide binding membrane proteins: phase separation of digitonin extracts to isolate the hyaluronate synthase from Streptococcus sp. in active form. Protein Expr. Purif. 7, 343-346, （1996） Abstract
  Nock, B., Extracti-Gel D chromatography is a simple efficient method for removing digitonin during receptor purification: application to the κ1 opioid receptor. J. Neurosci. Methods 50, 353, （1993） Abstract
Merck Merck 13,3183
Beilstein Beil. 19,V,3,603
  Aldrich MSDS 1, 695:B / Corp MSDS 1 （1）, 1253:C / RegBook 1 （2）, 2857:E / Sax 6, 1035 / Sigma FT-IR 1 （1）, 584:D

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