纺锤菌素二盐酸/Netropsin dihydrochlorideK0013-上海劲马实验设备有限公司

产品分类

生物试剂

您的位置：首页 > 产品中心 > 生物试剂 > 抗生素试剂 > K0013纺锤菌素二盐酸/Netropsin dihydrochloride

产品中心

: 产品名称： 纺锤菌素二盐酸/Netropsin dihydrochloride

产品型号： K0013

更新时间： 2017-07-16

描述：98%,超纯

在线询价 >联系我们 >

产品介绍

Description
Biochem/physiol Actions Unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
Caution Protect from light.

Properties
biological source from Streptomyces netropsis
assay ≥98% （HPLC and TLC）
form powder
color faint yellow
solubility H2O: 1 mg/mL
storage temp. −20°C

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
RIDADR UN2811 6.1/PG 3
WGK Germany 3
RTECS DW2973000

References
reference Zimmer, C., et al., Protection of （dA.dT） cluster regions in the DNAase I cleavage of DNA by specific interaction with netropsin. Nucleic Acids Res. 8, 2999-3010, （1980） Abstract
Beerman, T.A., et al., Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim. Biophys. Acta 1090, 52-60, （1991） Abstract
Poot, M., et al., Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerase I and II activity. Exp. Cell Res. 218, 326-330, （1995） Abstract
Poot, M., et al., The minor-groove binding DNA-ligands netropsin, distamycin A and berenil cause polyploidisation via impairment of the G2 phase of the cell cycle. Cell Struct. Funct. 15, 151-157, （1990） Abstract

Printable Reviews
Product ReviewsReview This Product

纺锤菌素二盐酸/Netropsin dihydrochloride

留言框

产品：

您的单位：

您的姓名：

联系电话：

常用邮箱：

省份：

详细地址：

补充说明：

验证码：