盐酸林可霉素/林肯霉素/盐酸洁霉素/6-（1-甲-反-丙基-L-2-吡咯烷甲酰氨基）-1-硫代-6,

 Description
Biochem/physiol Actions Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA.1
Mode of action: inhibits bacterial protein synthesis
Antimicrobial spectrum: Gram-positive bacteria

Properties
assay ≥90% （TLC）
potency 800-900 units per mg
storage temp. 2-8°C

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Gloves
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 2
RTECS RH6315000

References
Cited Reference 1. Kirillov, S. V., et al., Peptidyl transferase antibiotics perturb the relative positioning of the 3′-terminal adenosine of P/P′-site-bound tRNA and 23S rRNA in the ribosome RNA 5, 1003-1013, （1999）
reference Champney, W.S. and Tober, C.L., Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics Curr. Microbiol. 41, 126-135, （2000）

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