氟康唑/大扶康/麦尼芬/麦道氟康/Fluconazole

 Description
Biochem/physiol Actions Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.

Properties
assay ≥99% （HPLC）
form solid
solubility DMSO: 5 mg/mL
Gene Information human ... CYP1A2（1544）
storage temp. room temp

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Gloves
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS XZ4810000

References
reference Richardson, K., et al., Antifungal actvity in vivo. Antimicrob. Agents Chemother. 27, 832, （1985）
  Rogers, T.E., and Galgiani, J.N., Antifungal activity in vitro. Antimicrob. Agents Chemother. 30, 418, （1986）
  MacMillan, M.L., et al., Infection prophylaxis in bone marrow transplantation patients. Am. J. Med. 112, 369, （2002）

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