链脲佐菌素/链脲霉素/链氮霉素/链脲菌素/链佐星/链唑霉素/STZ/Streptozotocin

 Description
Biochem/physiol Actions An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

Properties
assay ≥98.0% （HPLC）
mp 121 °C （dec.）（lit.）
storage temp. −20°C

Safety
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes Xn
Risk Statements 40
Safety Statements 36/37
RIDADR UN3077 9/PG 3
WGK Germany 3
RTECS LZ5775000

References
Cited Reference 1. Bennett, R.A., and Pegg, A.E., Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41, 2786, （1981）
reference Bolzan, A.D., and Bianchi, M.S., Clastogenic effects of streptozotocin on human colon cancer cell lines with gene amplification. J. Environ. Pathol. Toxicol. Oncol. 22, 281-286, （2003）
  Oberg, K., Chemotherapy and biotherapy in the treatment of neuroendocrine tumours. Ann. Oncol. 12, S111-S114, （2001）
  Szkudelski T., The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50, 537-546, （2001）
Merck Merck 13,8912
  Corp MSDS 1 （2）, 3177:D / FT-IR 2 （1）, 1366:B / FT-NMR 1 （1）, 1313:B / RegBook 1 （1）, 945:A / Sax 6, 2469 / Structure Index 1, 147:D:1

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