盐酸强力霉素/盐酸脱氧土霉素/盐酸多西环素/Doxycycline HCl

 Description
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Biochem/physiol Actions Broad spectrum antibiotic; derivative of oxytetracycline. Broad spectrum inhibitor of matrix metalloproteinases in vivo.

Properties
assay ≥98% （TLC）
storage temp. 2-8°C

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Gloves
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
WGK Germany 3

References
reference Burggraf, D. et al., Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol. Dis. 25, 506-13, （2007）
  Franco, C. et al.,, Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am. J. Pathol. 168, 1697-709, （2006）
  Garcia, R.A. et al.,, Molecular interactions between matrilysin and the matrix mettalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol. Pharmacol. 67, 1128-36, （2005）
  Lamparter, S. et al., Doxycline and tissue repair in rats. J. Lab. Clin. Med. 139, 295-302, （2002）

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