腐草霉素/Phleomycin

 Description
Biochem/physiol Actions Phleomycin is a structurally related form of the antibiotic, bleomycin. Phleomycin blocks S-phase entry in the cell cycle. While phleomycin can damage DNA, like bleomycin, it is not used as an anticancer agent, but rather as a selection agent. The RAD6 DNA repair gene is essential for phleomycin resistance in mutant yeast.

Properties
form powder
color light blue
storage temp. 2-8°C

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Gloves
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
RTECS SY0525000

References
reference Robson, C.N., et al., Bleomycin and X-ray-hypersensitive Chinese hamster ovary cell mutants: genetic analysis and cross-resistance to neocarzinostatin. Mutat. Res. 193, 157-165, （1988） Abstract
  Povirk, L.F., et al., Copper（II）.bleomycin, iron（III）.bleomycin, and copper（II）.phleomycin: comparative study of deoxyribonucleic acid binding. Biochemistry 20, 665-671, （1981） Abstract
  Sleigh, M.J., and Grigg, G.W., Sulphydryl-mediated DNA breakage by phleomycin in Escherichia coli. Mutat. Res. 42, 181-190, （1977） Abstract
  He, C.H., et al., A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene. Can. J. Microbiol. 42, 1263-1266, （1996） Abstract

 Printable Reviews
Product ReviewsReview This Product
 

• K0105盐酸阿霉素/盐酸多柔比星/盐酸柔红霉素/阿得里亚霉素/14-羟正定霉素/阿霉素/DOX
• K0104磺胺甲噁唑/磺胺甲恶唑/磺胺甲基异恶唑/磺胺甲基异噁唑/新明磺/新诺明/3-对氨基苯磺酰胺基-5-甲
• K0103匹马霉素/纳他霉素/那他霉素/游霉素/匹马力星/无水奈伟拉平/Pimaricin
• K0102新生霉素
• K0046-1阿米卡星/丁胺卡那霉素/Amikacin
• K0101马来酸罗格列酮/5-[4-[2-[N-甲基-N-（2-吡啶基）氨基]-乙氧基]苄基]噻唑烷-2,4二
• K01005-氟胞嘧啶/氟胞嘧啶/4-氨基-5-氟-2（1H）-嘧啶酮/5-Fluorocytosine
• K0099呋喃唑酮/痢特灵/3-（5-硝基糠叉氨基）-2-唑烷酮/Furazolidone
• K0098磺胺嘧啶/磺胺嘧啶钠/2-对氨基苯磺酰胺嘧啶/磺胺哒嗪/地亚净/Sulfadiazine
• K0097磺胺二甲基嘧啶/磺胺双甲基嘧啶/磺胺间二甲氧嘧啶/4-氨基-N-（4，6-二甲基-2-嘧啶基）苯磺酰