磺胺甲噁唑/磺胺甲恶唑/磺胺甲基异恶唑/磺胺甲基异噁唑/新明磺/新诺明/3-对氨基苯磺酰胺基-5-甲

Description
Biochem/physiol Actions Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Properties
Gene Information rat ... Ednra（24326）

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Faceshields, Gloves
Hazard Codes Xi
Risk Statements 36/37/38-43
Safety Statements 26-36
WGK Germany 2
RTECS WP0700000

References
reference Then, R.L.,, Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole. Rev. Infect. Dis. 4, 261-269, （1982） Abstract
  Skold, O.,, Sulfonamide resistance: mechanisms and trends. Drug Resist. Updat. 3, 155-160, （2000） Abstract
Merck Merck 13,9003

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