放线菌素D/更生霉素/放线菌素C1/Actinomycin D

 Description
Biochem/physiol Actions An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Caution Hygroscopic and light sensitive.

Properties
biological source from Streptomyces sp.
assay ~98% （HPLC）
form powder
color red, powder
  red to orange
mp 251-253
solubility DMSO: 1 mg/mL
  ethanol: soluble
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes T+
Risk Statements 28
Safety Statements 22-28-36/37-45
RIDADR UN3462 6.1/PG 2
WGK Germany 3
RTECS AU1575000
 

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